Publications
For a full list of my publications, see Google Scholar
Synthesis and analysis of novel catecholic ligands as inhibitors of catechol-O-methyltransferase
A. Katherine Hatstat, Grace Kennedy, C. Skyler Cochrane, Larryn W. Peterson, Mauricio Cafiero. Bioorganic and Medicinal Chemistry Letters, 2023, 88, 129286. DOI: 10.1016/j.bmcl.2023.129286
Small Molecule Improvement of Trafficking Defects in Models of Neurodegeneration
A. Katherine Hatstat, Michael D. Pupi, Michaela C. Reinhart, and Dewey G. McCafferty, ACS Chemical Neuroscience, 2021. DOI: https://doi.org/10.1021/acschemneuro.1c00524
Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N-arylbenzimidazole ligand's rescue of Parkinson's-associated cell toxicity
A. Katherine Hatstat, Baiyi Quan, Morgan Bailey, Michael C. Fitzgerald, Michaela C. Reinhart, Dewey G. McCafferty, RSC Chemical Biology, 2022, Advance Article. DOI: https://doi.org/10.1039/D1CB00103E
Predicting PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases
A. Katherine Hatstat, Michael D. Pupi, and Dewey G. McCafferty, PLoS ONE, 2021. DOI: https://doi.org/10.1371/journal.pone.0258315
Synthesis and analysis of novel catecholic ligands as inhibitors of catechol-O-methyltransferase.
A. Katherine Hatstat, Grace Kennedy, C. Skyler Cochrane, Larryn W. Peterson, Mauricio Cafiero, in preparation.
Characterization of small-molecule induced changes in Parkinson’s-related trafficking and transport via the Nedd4 signaling pathway
A. Katherine Hatstat, Hannah D. Ahrendt, Matthew W. Foster, Leland Mayne, M. Arthur Moseley, S. Walter Englander, Dewey G. McCafferty, Cell Chemical Biology, 2021. DOI: 10.1016/j.chembiol.2020.10.008
BioRxiv pre-print: https://doi.org/10.1101/2020.06.01.128348
Robust and facile purification of full-length ubiquitin ligase human Nedd4 from Escherichia coli
A. Katherine Hatstat, Dewey G. McCafferty. Protein Expression and Purification, 2020. DOI: 10.1016/j.pep.2020.105649
Ab initio study of electronic interaction energies and desolvation energies for dopaminergic ligands in the catechol-O-methyltransferase active site
A. Katherine Hatstat, Mallory Morris, Larryn Peterson, and M. Cafiero. Computational and Theoretical Chemistry, 2016. DOI: 10.1016/j.comptc.2016.01.003.
MP2//DFT Calculations of Interaction Energies Between Acetaminophen and Acetaminophen Analogues and the Aryl Sulfotransferase Active Site
K.M. DiGiovanni, A. Katherine Hatstat, Jennifer Rote and M. Cafiero. Computational and Theoretical Chemistry, 2013. DOI: 10.1016/j.comptc.2016.01.003. DOI: 10.1016/j.comptc.2012.12.004
SELECTED PRESENTATIONS
ORAL
A. Katherine Hatstat, Vee Xu, and William F. DeGrado, “Protein design enables interrogation of bacterial signal transduction mechanisms,” Gibbs Society Annual Conference on Biothermodynamics, 2023 (upcoming)
A. Katherine Hatstat, Vee Xu, and William F. DeGrado, “Engineering bacterial signal transduction,” Leading Edge Symposium, HHMI Janelia Research Campus, 2023
A. Katherine Hatstat, Hannah D. Ahrendt, Dewey G. McCafferty, “Biochemical and chemoproteomic characterization reveals a novel protein network in small molecule rescue of Parkinson’s-related trafficking defects”, #ChemistsLive, ACS Cross-Division Virtual Live Content Event, 2020
A. Katherine Hatstat, Hannah D. Ahrendt, Dewey G. McCafferty. “Unravelling the druggability of Nedd4-dependent ubiquitin signaling in Parkinson’s disease”, St. Jude National Graduate Student Symposium, Memphis, TN, 2020 *Invited conference, CANCELLED DUE TO COVID-19
A. Katherine Hatstat, Dewey G. McCafferty. “Unravelling the druggability of E3 ubiquitin ligase Nedd4 as a target for the alleviation of α-synuclein toxicity in Parkinson’ s disease”, Southeast Regional Meeting of the American Chemical Society (SERMACS); Savannah, GA, 2019
POSTER
A. Katherine Hatstat, Vee Xu, and William F. DeGrado, “Protein design to re-engineer signal transduction in bacterial histidine kinases”, Gordon Research Conference: Protein Engineering; Smithfield, RI, 2023
A. Katherine Hatstat, Phillipp Heuttemann, William F. DeGrado. "Protein design to re-engineer bacterial histidine kinases", Sensory Transduction in Microorganisms Gordon Conference, Ventura, CA, 2022